Rift Valley Fever

Priority List of Adverse events of special interest for

Rift Valley Fever

AESI: Hemorrhagic disease
Specific to Rift Valley Fever disease:
Brighton Case Definition: End of 2023
Brighton CD Companion Guide: End of 2023

AESI: Thrombocytopenic Thrombosis Syndrome
Specific to Rift Valley Fever disease:
Specific to vaccine: Adeno vectors
Brighton Case Definition: End of 2023
Brighton CD Companion Guide: End of 2023

Body System: Immunologic

AESI: Anaphylaxis
Specific to vaccine: All
vaccines
Brighton Case Definition: Click to access
Brighton CD Companion Guide: Click to access

AESI: Thrombocytopenia
Specific to vaccine: All
vaccines
Brighton Case Definition: Click to access
Brighton CD Companion Guide: Click to access

Body System: Musculoskeletal

AESI: Acute aseptic arthritis
Specific to vaccine: VSV vector
Brighton Case Definition: Click to access
Brighton CD Companion Guide: End of 2023

Body System: Neurologic

AESI: Generalized convulsion
Specific to Rift Valley Fever disease:
Specific to vaccine: All
vaccines
Brighton Case Definition: Click to access
Brighton CD Companion Guide: Click to access

AESI: Aseptic meningitis
Specific to vaccine: Live attenuated viral vaccine
Brighton Case Definition: Click to access
Brighton CD Companion Guide: Click to access

AESI: Loss of Vision (incl uveitis, retinitis, optic neuritis)
Specific to Rift Valley Fever disease:
Brighton Case Definition: Prioritized, date TBD
Brighton CD Companion Guide: Prioritized, date TBD

AESI: Encephalitis
Specific to Rift Valley Fever disease:
Specific to vaccine: Live attenuated viral vaccine
Brighton Case Definition: Click to access
Brighton CD Companion Guide: Click to access

AESI: Myelitis
Specific to Rift Valley Fever disease:
Specific to vaccine: Live attenuated viral vaccine
Brighton Case Definition: Click to access
Brighton CD Companion Guide: Click to access

AESI: Guillain Barré Syndrome
Specific to Rift Valley Fever disease:
Specific to vaccine: Some vaccines¹
Brighton CD Companion Guide: TBD

Body System: Respiratory

AESI: Acute Respiratory Distress Syndrome
Specific to Rift Valley Fever disease:
Brighton Case Definition: Click to access
Brighton CD Companion Guide: Click to access

Body System: Pregnancy / Perinatal Outcomes

AESI: Spontaneous abortion
Specific to Rift Valley Fever disease:
Brighton Case Definition: Click to access
Brighton CD Companion Guide: Mid 2023

AESI: Stillbirth
Specific to Rift Valley Fever disease:
Brighton Case Definition: Click to access
Brighton CD Companion Guide: Mid 2023


Body System	AESI	Specific to Rift Valley Fever disease	Specific to vaccine platform	Brighton Case Definition	Brighton CD Companion Guide

Hematologic	Thrombocytopenic Thrombosis Syndrome	✅	Adenoviral vectors	End of 2023	End of 2023
Hematologic		Hemorrhagic disease	✅		End of 2023	End of 2023

Immunologic	Anaphylaxis		All vaccines	Click to access	Click to access
Immunologic	Immunologic	Thrombocytopenia		All vaccines	Click to access	Click to access

Musculoskeletal	Acute aseptic arthritis		VSV vector	Click to access	End of 2023

Neurologic	Generalized convulsion	✅	All vaccines	Click to access	Click to access
	Neurologic	Aseptic meningitis		Live attenuated viral vaccine	Click to access	Click to access
		Loss of Vision (incl uveitis, retinitis, optic neuritis)	✅		Prioritized, date TBD	Prioritized, date TBD
	Neurologic	Encephalitis	✅	Live attenuated viral vaccine	Click to access	Click to access
	Neurologic	Myelitis	✅	Live attenuated viral vaccine	Click to access	Click to access
	Neurologic	GBS	✅	Some vaccines¹		TBD

Respiratory	ARDS	✅		Click to access	Click to access

Pregnancy / Perinatal Outcomes	Spontaneous abortion	✅		Click to access	Mid 2023
Pregnancy / Perinatal Outcomes		Stillbirth	✅		Click to access	Mid 2023

¹Some seasonal influenza vaccines; monovalent H1N1 pandemic vaccine; COVID-19 ChAdOx-1 S vaccine.

Learn more about methods and results of the creation of the Priority List of potential Adverse events of special interest relevant to Rift Valley Fever vaccine trials HERE.