Priority List of Adverse events of special interest for
Chikungunya
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AESI: Myocarditis / Pericarditis
Specific to Chikungunya disease: 
Brighton Case Definition: Click to access
Brighton CD Companion Guide: Click to access
AESI: Thrombosis / Thromboembolism
Specific to Chikungunya disease:
Brighton Case Definition: Click to access
Brighton CD Companion Guide: Click to access
AESI: Hemorrhagic disease
Specific to Chikungunya disease:
Brighton Case Definition: End of 2023
Brighton CD Companion Guide: End of 2023
AESI: Thrombocytopenic Thrombosis Syndrome ²
Specific to vaccine: Adeno vectors
Brighton Case Definition: End of 2023
Brighton CD Companion Guide: End of 2023
AESI: Anaphylaxis
Specific to vaccine: All
vaccines
Brighton Case Definition: Click to access
Brighton CD Companion Guide: Click to access
AESI: Thrombocytopenia
Specific to Chikungunya disease:
Specific to vaccine: All
vaccines
Brighton Case Definition: Click to access
Brighton CD Companion Guide: Click to access
AESI: Acute aseptic arthritis
Specific to vaccine: VSV vector
Brighton Case Definition: Click to access
Brighton CD Companion Guide: Dec 2023
AESI: Acute/chronic Inflammatory Rheumatism
Specific to Chikungunya disease:
Brighton Case Definition:Prioritized, date TBD
Brighton CD Companion Guide:Prioritized, date TBD
AESI: Generalized convulsion
Specific to Chikungunya disease:
Specific to vaccine: All
vaccines
Brighton Case Definition: Click to access
Brighton CD Companion Guide: Click to access
AESI: Aseptic meningitis
Specific to Chikungunya disease:
Specific to vaccine: Live attenuated viral vaccine
Brighton Case Definition: Click to access
Brighton CD Companion Guide: Click to access
AESI: Acute Disseminated Encephalomyelitis
Specific to Chikungunya disease:
Brighton Case Definition: Click to access
Brighton CD Companion Guide: Click to access
AESI: Encephalitis
Specific to Chikungunya disease:
Specific to vaccine: Live attenuated viral vaccine
Brighton Case Definition: Click to access
Brighton CD Companion Guide: Click to access
AESI: Myelitis
Specific to Chikungunya disease:
Specific to vaccine: Live attenuated viral vaccine
Brighton Case Definition: Click to access
Brighton CD Companion Guide: Click to access
AESI: Guillain Barré Syndrome
Specific to Chikungunya disease:
Specific to vaccine: Some vaccines¹
Brighton Case Definition: Click to access
Brighton CD Companion Guide: Click to access
AESI: Bell’s Palsy
Specific to Chikungunya disease:
Brighton Case Definition: Click to access
Brighton CD Companion Guide: Click to access
AESI: Uveitis/Retinitis/Optic neuritis
Specific to Chikungunya disease:
Brighton Case Definition:Prioritized, date TBD
Brighton CD Companion Guide:Prioritized, date TBD
AESI: Alopecia
Specific to Chikungunya disease:
Brighton Case Definition: TBD
Brighton CD Companion Guide: TBD
AESI: Spontaneous abortion
Specific to Chikungunya disease:
Brighton Case Definition: Click to access
Brighton CD Companion Guide: Mid 2023
AESI: Stillbirth
Specific to Chikungunya disease:
Brighton Case Definition: Click to access
Brighton CD Companion Guide: Aug 2023
AESI: Maternal death
Specific to Chikungunya disease:
Brighton Case Definition: Click to access
Brighton CD Companion Guide: Aug 2023
AESI: Neonatal sepsis
Specific to Chikungunya disease:
Brighton Case Definition: Click to access
Brighton CD Companion Guide: TBD
AESI: Neonatal encephalopathy
Specific to Chikungunya disease:
Brighton Case Definition: Click to access
Brighton CD Companion Guide: TBD
AESI: Neurodevelopmental delay
Specific to Chikungunya disease:
Brighton Case Definition: Click to access
Brighton CD Companion Guide: TBD
1 Some seasonal influenza vaccines; monovalent H1N1 pandemic vaccine; COVID-19 ChAdOx-1 S vaccine.
Learn more about methods and results of the creation of the Priority List of potential Adverse events of special interest relevant to Chikungunya vaccine trials HERE.
SEE ALL THE LISTS OF AESIs FOR THE CEPI PRIORITIZED PATHOGENS:
