Priority List of Adverse events of special interest for
Lassa Fever
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AESI: Pericarditis
Specific to LF disease: 
Brighton Case Definition: Click to access
Brighton CD Companion Guide: Click to access
AESI: Myocarditis
Specific to vaccine: MVA¹
Brighton Case Definition: Click to access
Brighton CD Companion Guide: Click to access
AESI: Thrombosis with Thrombocytopenia Syndrome (TTS)
Specific to vaccine: Adenovirus vector
Brighton Case Definition: End of 2023
Brighton CD Companion Guide: End of 2023
AESI: Hemorrhage (internal, mucosal)
Specific to LF disease:
Brighton Case Definition: End of 2023
Brighton CD Companion Guide: End of 2023
AESI: Vascular leakage (edema, polyserositis)
Specific to LF disease:
Brighton Case Definition: TBD
Brighton CD Companion Guide:TBD
AESI: Thrombocytopenia
Specific to vaccines: All vaccines
Brighton Case Definition: Click to access
Brighton CD Companion Guide: Click to access
AESI: Anaphylaxis
Specific to LF disease:
Specific to vaccine: All
vaccines
Brighton Case Definition: Click to access
Brighton CD Companion Guide: Click to access
AESI: Thrombocytopenia
Specific to LF disease:
Specific to vaccine: All
vaccines
Brighton Case Definition: Click to access
Brighton CD Companion Guide: Click to access
AESI: Acute aseptic arthritis
Specific to vaccine: VSV vector
Brighton Case Definition: Click to access
Brighton CD Companion Guide: End of 2023
AESI: Generalized convulsion
Specific to vaccine: All
vaccines
Brighton Case Definition: Click to access
Brighton CD Companion Guide: Click to access
AESI: Aseptic meningitis
Specific to LF disease:
Specific to vaccine: Live attenuated viral vaccine
Brighton Case Definition: Click to access
Brighton CD Companion Guide: Click to access
AESI: Encephalitis
Specific to LF disease:
Specific to vaccine: Live attenuated viral vaccine
Brighton Case Definition: Click to access
Brighton CD Companion Guide: Click to access
AESI: Myelitis
Specific to LF disease:
Specific to vaccine: Live attenuated viral vaccine
Brighton Case Definition: Click to access
Brighton CD Companion Guide: Click to access
AESI: Sensorial Hearing Loss
Specific to LF disease:
Brighton Case Definition: Click to access
Brighton CD Companion Guide: Click to access
AESI: Guillain Barré Syndrome
Specific to vaccine: Some vaccines¹
Brighton CD Companion Guide: TBD
AESI: Alopecia
Specific to LF disease:
Brighton Case Definition: TBD
Brighton CD Companion Guide: TBD
AESI: Single Organ Cutaneous Vasculitis
Specific to vaccines: VSV Vector
Brighton Case Definition: Click to access
Brighton CD Companion Guide: Mid 2023
AESI: Spontaneous abortion
Specific to LF disease:
Brighton Case Definition: Click to access
Brighton CD Companion Guide: Mid 2023
AESI: Stillbirth
Specific to LF disease:
Brighton Case Definition: Click to access
Brighton CD Companion Guide: Mid 2023
AESI: Maternal death
Specific to LF disease:
Brighton Case Definition: Click to access
Brighton CD Companion Guide: TBD
AESI: Neonatal death
Specific to LF disease:
Brighton Case Definition: Click to access
Brighton CD Companion Guide: TBD
Body System | AESI | Specific to LF disease | Specific to | Brighton Case Definition | Brighton CD Companion Guide |
|---|---|---|---|---|---|
| Cardiac | Pericarditis | ✅☑️ | |||
| Myocarditis | ✅☑️ | MVA¹ | |||
| Hematologic | Thrombosis with Thrombocytopenia Syndrome (TTS) | Adenovirus vector | End of 2023 | End of 2023 | |
Hemorrhage (internal, mucosal) | ✅ | End of 2023 | End of 2023 | ||
| Vascular leakage (edema, polyserositis) | ✅ | TBD | TBD | ||
| Thrombocytopenia | All vaccines | ||||
| Immunologic | Anaphylaxis | ✅ | All vaccines | ||
| Thrombocytopenia | ✅ | All vaccines | |||
| Musculoskeletal | Acute aseptic arthritis | VSV vector | End of 2023 | ||
| Neurologic | Generalized convulsion | All vaccines | |||
| Aseptic meningitis | ✅ | Live attenuated viral vaccine | |||
| Encephalitis | ✅ | Live attenuated viral vaccine | |||
| Myelitis | ✅ | Live attenuated viral vaccine | |||
| Sensorial Hearing Loss | ✅ | ||||
| GBS | Some vaccines¹ | TBD | |||
| Dermatologic | Alopecia | ✅ | TBD | TBD | |
| Single Organ Cutaneous Vasculitis | VSV Vector | End of 2023 | |||
| Pregnancy / Perinatal Outcomes | Spontaneous abortion | ✅ | Mid 2023 | ||
| Stillbirth | ✅ | Mid 2023 | |||
| Maternal death | ✅ | TBD | |||
| Neonatal death | ✅ | TBD | |||
1 Some seasonal influenza vaccines; monovalent H1N1 pandemic vaccine; COVID-19 ChAdOx-1 S vaccine.
The list above is the most updated version of AESI for Lassa Fever. The complete version including the methods and literature evaluation will be available soon.
See the previous completed version HERE.
SEE ALL THE LISTS OF AESIs FOR THE CEPI PRIORITIZED PATHOGENS:
