Priority List of Adverse events of special interest for
MERS
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AESI: Pericarditis
Specific to MERS disease: 
Brighton Case Definition: Click to access
Brighton CD Companion Guide: Click to access
AESI: Thrombosis / Thromboembolism
Specific to MERS disease:
Brighton Case Definition: Click to access
Brighton CD Companion Guide: Click to access
AESI: Hemorrhagic disease
Specific to MERS disease:
Brighton Case Definition: End of 2023
Brighton CD Companion Guide: End of 2023
AESI: Thrombocytopenic Thrombosis Syndrome
Specific to vaccine: Adeno vectors
Brighton Case Definition: End of 2023
Brighton CD Companion Guide: End of 2023
AESI: Anaphylaxis
Specific to vaccine: All
vaccines
Brighton Case Definition: Click to access
Brighton CD Companion Guide: Click to access
AESI: Thrombocytopenia
Specific to vaccine: All
vaccines
Brighton Case Definition: Click to access
Brighton CD Companion Guide: Click to access
AESI: Vaccine-Associated Enhanced Disease
Specific to MERS disease:
Brighton Case Definition: Click to access
Brighton CD Companion Guide:Click to access
AESI: Acute aseptic arthritis
Specific to vaccine: VSV vector
Brighton Case Definition: Click to access
Brighton CD Companion Guide: End of 2023
AESI: Rhabdomyolysis
Specific to COVID-19 disease: –
Specific to vaccine: –
Brighton Case Definition: TBD
Brighton CD Companion Guide: TBD
AESI: Generalized convulsion
Specific to vaccine: All
vaccines
Brighton Case Definition: Click to access
Brighton CD Companion Guide: Click to access
AESI: Aseptic meningitis
Specific to vaccine: Live attenuated viral vaccine
Brighton Case Definition: Click to access
Brighton CD Companion Guide: Click to access
AESI: Acute Disseminated Encephalomyelitis
Specific to MERS disease:
Brighton Case Definition: Click to access
Brighton CD Companion Guide: Click to access
AESI: Encephalitis
Specific to MERS disease:
Specific to vaccine: Live attenuated viral vaccine
Brighton Case Definition: Click to access
Brighton CD Companion Guide: Click to access
AESI: Myelitis
Specific to MERS disease:
Specific to vaccine: Live attenuated viral vaccine
Brighton Case Definition: Click to access
Brighton CD Companion Guide: Click to access
AESI: Guillain Barré Syndrome
Specific to vaccine: Some vaccines¹
Brighton Case Definition: Click to access
Brighton CD Companion Guide: Click to access
AESI: Acute Respiratory Distress Syndrome
Specific to MERS disease:
Brighton Case Definition: Click to access
Brighton CD Companion Guide: Click to access
AESI: Spontaneous abortion
Specific to MERS disease:
Brighton Case Definition: Click to access
Brighton CD Companion Guide: Mid 2023
AESI: Stillbirth
Specific to MERS disease:
Brighton Case Definition: Click to access
Brighton CD Companion Guide: Mid 2023
AESI: Maternal death
Specific to MERS disease:
Brighton Case Definition: Click to access
Brighton CD Companion Guide: TBD
AESI: Neonatal death
Specific to MERS disease:
Brighton Case Definition: Click to access
Brighton CD Companion Guide: TBD
Body System | AESI | Specific to MERS disease | Specific to | Brighton Case Definition | Brighton CD Companion Guide |
|---|---|---|---|---|---|
| Cardiac | Pericarditis | ✅ ☑️ | |||
| Hematologic | Hemorrhagic disease | ✅ | End of 2023 | End of 2023 | |
Thrombocytopenic Thrombosis Syndrome | Adeno vectors | End of 2023 | End of 2023 | ||
| Thrombosis and Thromboembolism | ✅ | ||||
| Immunologic | Anaphylaxis | All vaccines | |||
| Thrombocytopenia | All vaccines | ||||
| VAED | ✅ | ||||
| Musculoskeletal | Acute aseptic arthritis | VSV vector | End of 2023 | ||
| Neurologic | Generalized convulsion | All vaccines | |||
| Aseptic meningitis | Live attenuated viral vaccine? | ||||
| ADEM | ✅ | ||||
| Encephalitis | ✅ | Live attenuated viral vaccine? | |||
| Myelitis | ✅ | Live attenuated viral vaccine? | |||
| GBS | Some vaccines¹ | ||||
| Respiratory | ARDS | ✅ | |||
| Pregnancy / Perinatal Outcomes | Spontaneous abortion | ✅ | Mid 2023 | ||
| Stillbirth | ✅ | Mid 2023 | |||
| Maternal death | ✅ | TBD | |||
| Neonatal death | ✅ | TBD | |||
1 Some seasonal influenza vaccines; monovalent H1N1 pandemic vaccine; COVID-19 ChAdOx-1 S vaccine.
Learn more about methods and results of the creation of the Priority List of potential Adverse events of special interest relevant to MERS vaccine trials HERE.
SEE ALL THE LISTS OF AESIs FOR THE CEPI PRIORITIZED PATHOGENS:
